We have many customers that consider iSCSI vs. NFS when implementing ESX to a NetApp or N-Series array. The pros and cons of iSCSI vs. NFS have been covered in depth many times in the past. My favorites are here and here . The story for NFS is very compelling vs. iSCSI but one big thing to consider is that VMWare Site Recovery Manager (SRM) isn’t supprted on NFS right now. Yes, I’m sure it will be supported eventually. But, if you have short range plans to implement SRM, make sure you take this fact into consideration.

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